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spr data analysis module  (Plexera Inc)

 
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    Plexera Inc spr data analysis module
    Spr Data Analysis Module, supplied by Plexera Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/spr data analysis module/product/Plexera Inc
    Average 90 stars, based on 1 article reviews
    spr data analysis module - by Bioz Stars, 2026-05
    90/100 stars

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    spr data analysis module  (Plexera Inc)
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    Plexera Inc spr data analysis module
    Spr Data Analysis Module, supplied by Plexera Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/spr data analysis module/product/Plexera Inc
    Average 90 stars, based on 1 article reviews
    spr data analysis module - by Bioz Stars, 2026-05
    90/100 stars
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    spr data analysis module software  (Plexera Inc)
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    Plexera Inc spr data analysis module software
    FIGURE 7 IATL directly binds to STAT3 in melanoma cells. (a) Molecular docking of IATL (PubChem CID: 73285), and STAT3 (PDB ID: 6NUQ) was performed using Autodock Vina 1.2. Three- dimensional binding mode of IATL (green) in complex with STAT3. (b) Two-dimensional binding mode of IATL in complex with STAT3. (c) Molecular dynamics (MD) simulation of surface crystal structure of STAT3-IATL complex at 0 ns (left panels) and 100 ns (right panels). (d) RMSD of all atoms of the STAT3 (green) and IATL (pink). (e) The <t>SPR</t> titration curve of IATL- STAT3 interaction. (f) CETSA for the binding of IATL to STAT3 protein in melanoma cell lysate. The thermal stability of STAT3 in cell lysates treated with IATL (100 μM) at different temperatures was determined by immunoblotting. Representative CETSA blot (left panel) and band intensity results analyzed using Image <t>J</t> <t>software</t> (right panel) are shown. ##p < 0.01, versus DMSO treatment.
    Spr Data Analysis Module Software, supplied by Plexera Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    spr data analysis module (dam)  (Plexera Inc)
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    FIGURE 7 IATL directly binds to STAT3 in melanoma cells. (a) Molecular docking of IATL (PubChem CID: 73285), and STAT3 (PDB ID: 6NUQ) was performed using Autodock Vina 1.2. Three- dimensional binding mode of IATL (green) in complex with STAT3. (b) Two-dimensional binding mode of IATL in complex with STAT3. (c) Molecular dynamics (MD) simulation of surface crystal structure of STAT3-IATL complex at 0 ns (left panels) and 100 ns (right panels). (d) RMSD of all atoms of the STAT3 (green) and IATL (pink). (e) The <t>SPR</t> titration curve of IATL- STAT3 interaction. (f) CETSA for the binding of IATL to STAT3 protein in melanoma cell lysate. The thermal stability of STAT3 in cell lysates treated with IATL (100 μM) at different temperatures was determined by immunoblotting. Representative CETSA blot (left panel) and band intensity results analyzed using Image <t>J</t> <t>software</t> (right panel) are shown. ##p < 0.01, versus DMSO treatment.
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    FIGURE 7 IATL directly binds to STAT3 in melanoma cells. (a) Molecular docking of IATL (PubChem CID: 73285), and STAT3 (PDB ID: 6NUQ) was performed using Autodock Vina 1.2. Three- dimensional binding mode of IATL (green) in complex with STAT3. (b) Two-dimensional binding mode of IATL in complex with STAT3. (c) Molecular dynamics (MD) simulation of surface crystal structure of STAT3-IATL complex at 0 ns (left panels) and 100 ns (right panels). (d) RMSD of all atoms of the STAT3 (green) and IATL (pink). (e) The SPR titration curve of IATL- STAT3 interaction. (f) CETSA for the binding of IATL to STAT3 protein in melanoma cell lysate. The thermal stability of STAT3 in cell lysates treated with IATL (100 μM) at different temperatures was determined by immunoblotting. Representative CETSA blot (left panel) and band intensity results analyzed using Image J software (right panel) are shown. ##p < 0.01, versus DMSO treatment.

    Journal: Phytotherapy research : PTR

    Article Title: Isoalantolactone exerts anti-melanoma effects via inhibiting PI3K/AKT/mTOR and STAT3 signaling in cell and mouse models.

    doi: 10.1002/ptr.8132

    Figure Lengend Snippet: FIGURE 7 IATL directly binds to STAT3 in melanoma cells. (a) Molecular docking of IATL (PubChem CID: 73285), and STAT3 (PDB ID: 6NUQ) was performed using Autodock Vina 1.2. Three- dimensional binding mode of IATL (green) in complex with STAT3. (b) Two-dimensional binding mode of IATL in complex with STAT3. (c) Molecular dynamics (MD) simulation of surface crystal structure of STAT3-IATL complex at 0 ns (left panels) and 100 ns (right panels). (d) RMSD of all atoms of the STAT3 (green) and IATL (pink). (e) The SPR titration curve of IATL- STAT3 interaction. (f) CETSA for the binding of IATL to STAT3 protein in melanoma cell lysate. The thermal stability of STAT3 in cell lysates treated with IATL (100 μM) at different temperatures was determined by immunoblotting. Representative CETSA blot (left panel) and band intensity results analyzed using Image J software (right panel) are shown. ##p < 0.01, versus DMSO treatment.

    Article Snippet: All data were generated and analyzed using Plexera SPR Data analysis Module software (Plexera, USA).

    Techniques: Binding Assay, Titration, Western Blot, Software